Head to Head Analysis: PDL BioPharma (NASDAQ:PDLI) and Crispr Therapeutics (NASDAQ:CRSP)

PDL BioPharma (NASDAQ:PDLI) and Crispr Therapeutics (NASDAQ:CRSP) are both medical companies, but which is the superior business? We will compare the two companies based on the strength of their valuation, dividends, institutional ownership, analyst recommendations, risk, profitability and earnings.


This table compares PDL BioPharma and Crispr Therapeutics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
PDL BioPharma -32.13% 6.86% 5.17%
Crispr Therapeutics -8,839.02% -50.90% -39.83%

Analyst Ratings

This is a breakdown of current ratings and price targets for PDL BioPharma and Crispr Therapeutics, as reported by MarketBeat.com.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
PDL BioPharma 0 1 0 0 2.00
Crispr Therapeutics 2 3 7 0 2.42

PDL BioPharma currently has a consensus target price of $3.00, indicating a potential downside of 5.36%. Crispr Therapeutics has a consensus target price of $49.14, indicating a potential downside of 0.08%. Given Crispr Therapeutics’ stronger consensus rating and higher possible upside, analysts plainly believe Crispr Therapeutics is more favorable than PDL BioPharma.

Insider & Institutional Ownership

96.5% of PDL BioPharma shares are owned by institutional investors. Comparatively, 49.0% of Crispr Therapeutics shares are owned by institutional investors. 2.2% of PDL BioPharma shares are owned by insiders. Comparatively, 21.4% of Crispr Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company is poised for long-term growth.

Volatility and Risk

PDL BioPharma has a beta of 0.67, indicating that its share price is 33% less volatile than the S&P 500. Comparatively, Crispr Therapeutics has a beta of 3.11, indicating that its share price is 211% more volatile than the S&P 500.

Earnings & Valuation

This table compares PDL BioPharma and Crispr Therapeutics’ top-line revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
PDL BioPharma $198.11 million 1.91 -$68.86 million $0.37 8.57
Crispr Therapeutics $3.12 million 834.01 -$164.98 million ($3.44) -14.30

PDL BioPharma has higher revenue and earnings than Crispr Therapeutics. Crispr Therapeutics is trading at a lower price-to-earnings ratio than PDL BioPharma, indicating that it is currently the more affordable of the two stocks.


PDL BioPharma beats Crispr Therapeutics on 8 of the 14 factors compared between the two stocks.

About PDL BioPharma

PDL BioPharma, Inc. acquires, manages, and commercializes commercial stage pharmaceutical assets and late clinical stage pharmaceutical products in the United States, Europe, and internationally. The company operates in three segments: Pharmaceutical, Medical Devices, and Income Generating Assets. The Pharmaceutical segment manufactures, markets, and sells prescription medicine products for the treatment of hypertension to wholesalers under the Tekturna and Tekturna HCT names in the United States, as well as under the Rasilez and Rasilez HCT names internationally. The Medical Devices segment manufactures, markets, and sells LENSAR laser systems for anterior capsulotomy, lens fragmentation, corneal and arcuate incisions to ophthalmic ambulatory surgical centers, specialty ophthalmic hospitals, and multi-specialty hospitals through a direct sales force. The Income Generating Assets segment consists of notes and other long-term receivables; royalty rights and hybrid notes/royalty receivables; equity investments in healthcare companies; and royalties from issued patents covering the humanization of antibodies, including Avastin, Herceptin, Xolair, Lucentis, Perjeta, Kadcyla, and Tysabri. The company was formerly known as Protein Design Labs, Inc. and changed its name to PDL BioPharma, Inc. in 2006. PDL BioPharma, Inc. was founded in 1986 and is headquartered in Incline Village, Nevada.

About Crispr Therapeutics

CRISPR Therapeutics AG, a gene editing company, focuses on developing transformative gene-based medicines for the treatment of serious human diseases using its regularly interspaced short palindromic repeats associated protein-9 (CRISPR/Cas9) gene-editing platform in Switzerland. Its lead product candidate is CTX001, an ex vivo CRISPR gene-edited therapy for treating patients suffering from dependent beta thalassemia or severe sickle cell disease in which a patient's hematopoietic stem cells are engineered to produce high levels of fetal hemoglobin in red blood cells. The company is also developing CTX110, a donor-derived gene-edited allogeneic CAR-T therapy targeting cluster of differentiation 19 positive malignancies. In addition, it is developing allogeneic CAR-T programs targeting B-Cell maturation antigen and CD70; CTX120, a CAR-T cell product candidate for the treatment of multiple myeloma; CTX130 for the treatment of solid tumors and hematologic malignancies; programs to treat Hurler Syndrome and severe combined immunodeficiency disease, as well as glycogen storage disease Ia; and programs targeting diseases, such as Duchenne muscular dystrophy and cystic fibrosis. It has a collaboration agreements with Vertex Pharmaceuticals, Incorporated and Vertex Pharmaceuticals (Europe) Limited to develop, manufacture, commercialize, sell, and use various therapeutics; and StrideBio LLC to develop adeno-associated viral capsids. The company also has research collaboration agreements with Neon Therapeutics for developing neoantigen-based therapeutic vaccines and T cell therapies; Massachusetts General Hospital Cancer Center to develop T cell therapies for cancer; ViaCyte, Inc. for designing, developing, and commercializing gene-edited allogeneic stem cell therapies for the treatment of diabetes; and ProBioGen AG to develop novel in vivo delivery modalities for CRISPR/Cas9. CRISPR Therapeutics AG is headquartered in Zug, Switzerland.

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